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genome-scale discovery of dna-methylation biomarkers for blood-based detection of colorectal cancer公司发现的dna甲基化生物标志物blood-based检测结直肠癌.pdf

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genome-scale discovery of dna-methylation biomarkers for blood-based detection of colorectal cancer公司发现的dna甲基化生物标志物blood-based检测结直肠癌

Genome-Scale Discovery of DNA-Methylation Biomarkers for Blood-Based Detection of Colorectal Cancer 1,4 6 8 1 Christopher P. E. Lange , Mihaela Campan , Toshinori Hinoue , Roderick F. Schmitz , Andrea E. van der 5 5 2 3 8 Meulen-de Jong , Hilde Slingerland , Peter J. M. J. Kok , Cornelis M. van Dijk , Daniel J. Weisenberger , 8 4 6,7,8 Hui Shen , Robertus A. E. M. Tollenaar , Peter W. Laird * 1 Department of Surgery, Groene Hart Hospital, Gouda, The Netherlands, 2 Department of Clinical Chemistry, Groene Hart Hospital, Gouda, The Netherlands, 3 Department of Pathology, Groene Hart Hospital, Gouda, The Netherlands, 4 Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands, 5 Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands, 6 Department of Surgery, University of Southern California, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, Los Angeles, California, United States of America, 7 Department of Biochemistry and Molecular Biology, University of Southern California, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, Los Angeles, California, United States of America, 8 USC Epigenome Center, University of Southern California, Los Angeles, California, United States of America Abstract Background: There is an increasing demand for accurate biomarkers for early non-invasive colorectal cancer detection. We employed a genome-scale mark