gene expression signatures that predict radiation exposure in mice and humans基因表达特征,预测辐射暴露在小鼠和人类.pdfVIP

PLoS MEDICINE Gene Expression Signatures That Predict Radiation Exposure in Mice and Humans 1,2 3 3 3 3 1 Holly K. Dressman , Garrett G. Muramoto , Nelson J. Chao , Sarah Meadows , Dawn Marshall , Geoffrey S. Ginsburg , Joseph R. Nevins1,2, John P. Chute1,3* 1 Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina, United States of America, 2 Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America, 3 Division of Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America Funding: This research was A B S T R A C T supported, in part, by grant AI- 067798–01 from the National Institutes of Allergy and Infectious Diseases (JRN and JPC). The funders Background had no role in study design, data collection and analysis, decision to The capacity to assess environmental inputs to biological phenotypes is limited by methods publish, or preparation of the that can accurately and quantitatively measure these contributions. One such example can be manuscript. seen in the context of exposure to ionizing radiation. Competing Interests: The authors have declared that no competing interests exist. Methods and Findings Academic Editor: Christopher We have made use of gene expression analysis of peripheral blood (PB) mononuclear cells to Kemp, Fred Hutchinson Cancer develop expression profiles that accurately reflect prior radiation