genome-wide analysis in brazilian xavante indians reveals low degree of admixture全基因组分析巴西xavante印第安人揭示了低程度的外加剂.pdfVIP
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genome-wide analysis in brazilian xavante indians reveals low degree of admixture全基因组分析巴西xavante印第安人揭示了低程度的外加剂
Genome-Wide Analysis in Brazilian Xavante Indians Reveals Low Degree of Admixture 1 ´ 2 ´ ´ 2 ˜ 1 Patricia C. Kuhn , Andrea R. V. Russo Horimoto , Jose Maurıcio Sanches , Joao Paulo B. Vieira Filho , Luciana Franco1, Amaury Dal Fabbro3, Laercio Joel Franco3, Alexandre C. Pereira2, Regina S. Moises 1* ˜ ˜ 1 Disciplina de Endocrinologia, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, 2 Laboratory of Genetics and Molecular Cardiology, Heart ˜ ˜ ˜ ˜ Institute, Medical School of University of Sao Paulo, Sao Paulo, Brazil, 3 Departamento de Medicina Social, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao ˜ Paulo, Ribeirao Preto, Brazil Abstract Characterization of population genetic variation and structure can be used as tools for research in human genetics and population isolates are of great interest. The aim of the present study was to characterize the genetic structure of Xavante Indians and compare it with other populations. The Xavante, an indigenous population living in Brazilian Central Plateau, is one of the largest native groups in Brazil. A subset of 53 unrelated subjects was selected from the initial sample of 300 Xavante Indians. Using 86,197 markers, Xavante were compared with all populations of HapMap Phase III and HGDP-CEPH projects and with a Southeast Brazilian population sample to establish its population
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