gene mutations and genomic rearrangements in the mouse as a result of transposon mobilization from chromosomal concatemers基因突变和基因重组导致鼠标转座子从染色体串联体动员.pdfVIP

Gene Mutations and Genomic Rearrangements in the Mouse as a Result of Transposon Mobilization from Chromosomal Concatemers 1,2 2,3 2,3 4 5 6 6 Aron M. Geurts , Lara S. Collier , Jennifer L. Geurts , Leann L. Oseth , Matthew L. Bell , David Mu , Robert Lucito , Susan A. Godbout1 2 7 3,4,8 9 , Laura E. Green , Scott W. Lowe , Betsy A. Hirsch , Leslie A. Leinwand , David A. Largaespada1,2,3* 1 Department of Genetics, Cell Biology, and Development, University of Minnesota Twin Cities, Minneapolis, Minnesota, United States of America, 2 The Arnold and Mabel Beckman Center for Transposon Research, University of Minnesota Twin Cities, Minneapolis, Minnesota, United States of America, 3 Cancer Center, University of Minnesota Twin Cities, Minneapolis, Minnesota, United States of America, 4 Institute of Human Genetics, University of Minnesota Twin Cities, Minneapolis, Minnesota, United States of America, 5 Department of Integrative Physiology, University of Colorado, Boulder, Colorado, United States of America, 6 Genome Research Center, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America, 7 Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America, 8 Laboratory Medicine and Pathology, University of Minnesota Twin Cities, Minneapolis, Minnesota, United States of America, 9 Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado, United States of America Previous studies of the Sleeping Beauty (SB) transposon system, as an insertional mutagen in the germline of mice, have used reverse genetic approaches. These studies have led to its propos