galectin-8 promotes cytoskeletal rearrangement in trabecular meshwork cells through activation of rho signalinggalectin-8促进细胞骨架重排在小梁网细胞通过激活ρ信号.pdfVIP
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galectin-8 promotes cytoskeletal rearrangement in trabecular meshwork cells through activation of rho signalinggalectin-8促进细胞骨架重排在小梁网细胞通过激活ρ信号
Galectin-8 Promotes Cytoskeletal Rearrangement in Trabecular Meshwork Cells through Activation of Rho Signaling 1. 1. 2 2 3 4,5 Shiri Diskin , Wei-Sheng Chen , Zhiyi Cao , Smita Gyawali , Haiyan Gong , Andrea Soza , ´ 4,5, Noorjahan Panjwani1,2,6* Alfonso Gonzalez 1 Program in Cell, Molecular Developmental Biology, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts, United States of America, 2 New England Eye Center and Department of Ophthalmology, Tufts University, Boston, Massachusetts, United States of America, 3 Department of Ophthalmology, ´ ´ ´ Boston University School of Medicine, Boston, Massachusetts, United States of America, 4 Departamento de Inmunologıa Clınica y Reumatologıa, Facultad de Medicina, ´ ´ ´ ´ ´ Centro de Regulacion Celular y Patologıa and Centro de Envejecimiento y Regeneracion, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile, 5 Millennium Institute for Fundamental and Applied Biology, Santiago, Chile, 6 Department of Biochemistry, Tufts University, Boston, Massachusetts, United States of America Abstract Purpose: The trabecular meshwork (TM) cell-matrix interactions and factors that influence Rho signaling in TM cells are thought to play a pivotal role in the regulation of aqueous outflow. The current study was designed to evaluate the role of a carbohydrate-binding protein, galectin-8 (Gal
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