有哪些信誉好的足球投注网站flanking bases influence the nature of dna distortion by platinum 1,2-intrastrand (gg) cross-links侧翼基地由铂1影响dna扭曲的本质,2-intrastrand(gg)交叉连接.pdfVIP
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flanking bases influence the nature of dna distortion by platinum 1,2-intrastrand (gg) cross-links侧翼基地由铂1影响dna扭曲的本质,2-intrastrand(gg)交叉连接
Flanking Bases Influence the Nature of DNA Distortion by Platinum 1,2-Intrastrand (GG) Cross-Links 1. 1,2. 1 1 Debadeep Bhattacharyya , Srinivas Ramachandran , Shantanu Sharma , Wimal Pathmasiri , 1 3 3 3,4 Candice L. King , Irene Baskerville-Abraham , Gunnar Boysen , James A. Swenberg , Sharon L. Campbell1,4*, Nikolay V. Dokholyan1,4*, Stephen G. Chaney1,4* 1 Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, United States of America, 2 Program in Cellular and Molecular Biophysics, University of North Carolina, Chapel Hill, North Carolina, United States of America, 3 Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, North Carolina, United States of America, 4 Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America Abstract The differences in efficacy and molecular mechanisms of platinum anti-cancer drugs cisplatin (CP) and oxaliplatin (OX) are thought to be partially due to the differences in the DNA conformations of the CP and OX adducts that form on adjacent guanines on DNA, which in turn influence the binding of damage-recognition proteins that control downstream effects of the adducts. Here we report a comprehensive comparison of the structural distortion of DNA caused by CP and OX adducts in the TGGT sequence context using nuclear magnetic resonance (NMR) spectroscopy and molecular dynamics (MD) simulations. When compared
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