什么是平均动力学温度.pdfVIP

WHAT IS MEAN KINETIC TEMPERATURE? 什么是平均动力学温度？ Mean Kinetic Temperature (MKT) is a simplified way of expressing the overall effect of temperature fluctuations during storage or transit of perishable goods. 平均动力学温度 （MKT）一种简单明了的反应温度波动对不耐久货物在储存和输运时的影 响。 Consider the following example. 参考一下例子： Example: 例： A dozen eggs sat: 一打鸡蛋放置在： In a 20º C room for 2 hours 20℃的房间放置2 小时 In 2º C refrigeration for 4 hours 2℃的冰箱放置4 小时 And on a 25º C loading dock for 1 hour 25℃码头放置1 小时 Using MKT we can calculate that temperature profile of the eggs was “thermally equivalent” to storing them at 15.7º C for 7 hours. 使用MKT，我们可以计算出上述情况等同于鸡蛋在15.7℃放置7 小时 HOW IS MEAN KINETIC TEMPERATURE CALCULATED? 平均动力学温度怎么计算？ Technically speaking, MKT is an expression of cumulative thermal stress experienced by a product at varying temperatures during storage and distribution. In other words, MKT is a calculated, single temperature that is analogous to the effects of temperature variations over a period of time. 严格的来说，平均动力学温度 （MKT）是一种产品在温度不断变化的储存或分销过程中的 累积热效力表现方式。换句话来说，MKT 是用单一温度来近似计算一段时间温度不断变化 1 / 4 的影响。 MKT is not a simple weighted average. The calculation of MKT gives the higher temperatures a greater weight when computing the average than would a simple numerical average or an arithmetic mean. This weighting is determined by a geometric transformation--the natural logarithm of the absolute temperature. MKT 不是简单的计算平均值， MKT 计算值一般比简单的数值平均值或算术平均值有更高 的加权。这种加权取决于绝对温度自然对数的几何转换。 The International Conference on Harmonization (ICH) stability testing guidelines define MKT as “a single derived temperature, which, if maintained over a defined period, would afford the same thermal challenge to a pharmaceutical product as would have been experienced over a ra