a unique feature of iron loss via close adhesion of helicobacter pylori to host erythrocytes缺铁的一个独特的特征通过密切的幽门螺旋杆菌粘附宿主红细胞.pdfVIP

A Unique Feature of Iron Loss via Close Adhesion of Helicobacter pylori to Host Erythrocytes 1 2 2 1 1 1 1 1 Zhiwei Wang , Lijuan Zhang , Zhi Guo , Lei Liu , Jun Ji , Jianian Zhang , Xuehua Chen , Bingya Liu , 1 3 3 4 1 1 Jun Zhang , Qiulan Ding , Xuefeng Wang , Wei Zhao , Zhenggang Zhu *, Yingyan Yu * 1 Shanghai Institute of Digestive Surgery and Department of Surgery, Shanghai Ruijin Hospital, Shanghai Key Laboratory for Gastric Neoplasia, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 2 Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Science, Shanghai, China, 3 Department of Transfusion and Clinical Biochemistry, Shanghai Ruijin Hospital, Shanghai, China, 4 Department of Medical Microbiology and Parasitology, Shanghai Jiao Tong University School of Medicine, Shanghai, China Abstract Iron deficiency anemia is an extra-stomach disease experienced in H. pylori carriers. Individuals with type A blood are more prone to suffering from H. pylori infection than other individuals. To clarify the molecular mechanisms underlying H. pylori- associated anemia, we collected erythrocytes from A, B, O, and AB blood donors and analyzed morphology, the number of erythrocytes with H. pylori colonies attached to them, and iron contents in erythrocytes and H. pylori (NCTC11637 and SS1 strains) by means of optical microscopy, scanning electron microscopy, and synchrotron radiation soft X-ray imaging. The number of type A erythrocytes with H. pylori attached to them was significantly higher than that of other erythrocytes