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a review of family-based tests for linkage disequilibrium between a quantitative trait and a genetic marker回顾家庭测试之间的连锁不平衡量化特征和遗传标记
Review
A Review of Family-Based Tests for Linkage
Disequilibrium between a Quantitative Trait and a
Genetic Marker
1 2 3
Warren J. Ewens *, Mingyao Li , Richard S. Spielman
1 Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, 2 Department of Biostatistics and Epidemiology, University of
Pennsylvania, Philadelphia, Pennsylvania, United States of America, 3 Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of
America
(/csg/abecasis/QTDT/) packages. Spe-
Abstract: Quantitative trait transmission/disequilibrium cifically we discuss the ‘‘Rabinowitz’’ [2] and the ‘‘Monks-Kaplan’’
tests (quantitative TDTs) are commonly used in family- [3] procedures, as well as various ‘‘Abecasis’’ [4] and ‘‘Allison’’ [5]
based genetic association studies of quantitative traits. regression-based procedures, when applied specifically to family trio
Despite the availability of various quantitative TDTs, some data. The questions addressed in this review are as follows:
users are not aware of the properties of these tests and
the relationships between them. This review aims at (a) What are the properties of the various Allison/Abecasis
outlining the broad features of the various quantitative regression-based tests and the Rabinowitz and the Monks-
TDT procedures carried out in the frequently used QTDT Kaplan tests?
and FBAT packages. Specifically, we discuss the ‘‘Rabino-
(b) What is the relation between the regr
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