有哪些信誉好的足球投注网站a vaccine against nicotine for smoking cessation a randomized controlled trial疫苗尼古丁戒烟一个随机对照试验.pdfVIP
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a vaccine against nicotine for smoking cessation a randomized controlled trial疫苗尼古丁戒烟一个随机对照试验
A Vaccine against Nicotine for Smoking Cessation: A Randomized Controlled Trial 1,2 3 3 4 5 Jacques Cornuz *, Susanne Zwahlen , Walter Felix Jungi , Joseph Osterwalder , Karl Klingler , Guy van 6 1 1 ¨ 7 ¨ 7 7 Melle , Yolande Bangala , Idris Guessous , Philipp Muller , Jorg Willers , Patrik Maurer , Martin F. Bachmann7, Thomas Cerny3 1 Department of Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland, 2 Department of Ambulatory Care and Community Medicine, Lausanne University Hospital, Lausanne, Switzerland, 3 Department of Internal Medicine, Kantonsspital, St.Gallen, Switzerland, 4 Emergency Department, Kantonsspital, St.Gallen, ¨ Switzerland, 5 Lung Center Hirslanden, Zurich, Switzerland, 6 Institute of Social and Preventive Medicine, University of Lausanne, Lausanne, Switzerland, 7 Cytos Biotechnology AG, Schlieren, Switzerland Abstract Background: Tobacco dependence is the leading cause of preventable death and disabilities worldwide and nicotine is the main substance responsible for the addiction to tobacco. A vaccine against nicotine was tested in a 6-month randomized, double blind phase II smoking cessation study in 341 smokers with a subsequent 6-month follow-up period. Methodology/Principal Findings: 229 subjects were randomized to receive five intramuscular injections of the nicotine vaccine and 112 to receive placebo at monthly intervals. All subjects received individual behavioral smoking cessation counseling. The vaccine was safe, generally well tolerated and highly immunogenic, inducing a 100% ant
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