有哪些信誉好的足球投注网站a review of adult mortality due to 2009 pandemic (h1n1) influenza a in california回顾成人死亡率由于2009年大流感(h1n1)流感在加州.pdfVIP
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a review of adult mortality due to 2009 pandemic (h1n1) influenza a in california回顾成人死亡率由于2009年大流感(h1n1)流感在加州
A Review of Adult Mortality Due to 2009 Pandemic
(H1N1) Influenza A in California
Janice K. Louie*, Cynthia Jean, Meileen Acosta, Michael C. Samuel, Bela T. Matyas, Robert Schechter
California Department of Public Health, Richmond, California, United States of America
Abstract
Background: While children and young adults had the highest attack rates due to 2009 pandemic (H1N1) influenza A (2009
H1N1), studies of hospitalized cases noted high fatality in older adults. We analyzed California public health surveillance
data to better characterize the populations at risk for dying due to 2009 H1N1.
Methods and Findings: A case was an adult $20 years who died with influenza-like symptoms and laboratory results
indicative of 2009 H1N1. Demographic and clinical data were abstracted from medical records using a standardized case
report form. From April 3, 2009 – August 10, 2010, 541 fatal cases $20 years with 2009 H1N1 were reported. Influenza
fatality rates per 100,000 population were highest in persons 50–59 years (3.5; annualized rate = 2.6) and 60–69 years (2.3;
annualized rate = 1.7) compared to younger and older age groups (0.4–1.9; annualized rates = 0.3–1.4). Of 486 cases
hospitalized prior to death, 441 (91%) required intensive care unit (ICU) admission. ICU admission rates per 100,000
population were highest in adults 50–59 years (8.6). ICU case-fatality ratios among adults ranged from 24–42%, with the
highest ratios in persons 70–79 years. A total of 425 (80%) cases had co-morbid conditions associated with severe seasonal
influenza. The prevalence of most co-morbid conditions increased with increasing age, but obesity, pregnancy and
obstructive sleep apnea decreased with age. Rapid testing was positive in 97 (35%) of 276 tested. Of 482 ca
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