a validated model of serum anti-müllerian hormone from conception to menopause血清她们血液中的抗苗勒氏管激素的验证模型从概念到更年期.pdfVIP

¨ A Validated Model of Serum Anti-Mullerian Hormone from Conception to Menopause 1 2 3 4 5 Thomas W. Kelsey , Phoebe Wright , Scott M. Nelson , Richard A. Anderson , W. Hamish B. Wallace * 1 School of Computer Science, University of St. Andrews, St. Andrews, Scotland, United Kingdom, 2 University of Edinburgh, Edinburgh, Scotland, United Kingdom, 3 Centre for Population and Health Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom, 4 MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, Scotland, United Kingdom, 5 Division of Reproductive and Developmental Sciences, University of Edinburgh, Edinburgh, Scotland, United Kingdom Abstract ¨ Background: Anti-Mullerian hormone (AMH) is a product of growing ovarian follicles. The concentration of AMH in blood may also reflect the non-growing follicle (NGF) population, i.e. the ovarian reserve, and be of value in predicting reproductive lifespan. A full description of AMH production up to the menopause has not been previously reported. Methodology/Principal Findings: By searching the published literature for AMH concentrations in healthy pre-menopausal females, and using our own data (combined n ~3,260) we have generated and robustly validated the first model of AMH concentration from conception to menopause. This model shows that 34% of the variation in AMH is due to age alone. We have shown that AMH peaks at age 24.5 years, followed by a decline to the menopause. We have also shown that there is a neonatal peak and a potential pre-pubertal peak. Our model allows us to generate n