a snapshot of histone modifications within transposable elements in drosophila wild type strains转座因子的快照中组蛋白修饰在果蝇野生型菌株.pdfVIP

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a snapshot of histone modifications within transposable elements in drosophila wild type strains转座因子的快照中组蛋白修饰在果蝇野生型菌株.pdf

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a snapshot of histone modifications within transposable elements in drosophila wild type strains转座因子的快照中组蛋白修饰在果蝇野生型菌株

A Snapshot of Histone Modifications within Transposable Elements in Drosophila Wild Type Strains 1¤a ´ 2¤b 3 3 2 1 Rita Rebollo , Beatrice Horard , Flora Begeot , Marion Delattre , Eric Gilson , Cristina Vieira * ´ ´ ´ 1 Laboratoire de Biometrie et Biologie Evolutive, UMR5558, CNRS, Universite de Lyon, Universite Lyon 1, Villeurbanne, France, 2 Institute of Research on Cancer and Aging, ´ ´ ´ ´ ´ ´ ` ` CNRS UMR7284/INSERM U1081/UNS Faculte de Medecine, Nice, France, 3 Departement de Genetique et Evolution, Universite de Geneve, Geneve, Switzerland Abstract Transposable elements (TEs) are a major source of genetic variability in genomes, creating genetic novelty and driving genome evolution. Analysis of sequenced genomes has revealed considerable diversity in TE families, copy number, and localization between different, closely related species. For instance, although the twin species Drosophila melanogaster and D. simulans share the same TE families, they display different amounts of TEs. Furthermore, previous analyses of wild type derived strains of D. simulans have revealed high polymorphism regarding TE copy number within this species. Several factors may influence the diversity and abundance of TEs in a genome, including molecular mechanisms such as epigenetic factors, which could be a source of variation in TE success. In this paper, we present the first analysis of the epigenetic status of four TE families (roo, tirant, 412 and F) in seven wild type strains