有哪些信誉好的足球投注网站a sodium leak current regulates pacemaker activity of adult central pattern generator neurons in lymnaea stagnalis钠泄漏电流调节起搏器活动的成年中枢模式发生器神经元椎实螺属stagnalis.pdfVIP
- 1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
a sodium leak current regulates pacemaker activity of adult central pattern generator neurons in lymnaea stagnalis钠泄漏电流调节起搏器活动的成年中枢模式发生器神经元椎实螺属stagnalis
A Sodium Leak Current Regulates Pacemaker Activity of Adult Central Pattern Generator Neurons in Lymnaea Stagnalis Tom Z. Lu, Zhong-Ping Feng* Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada Abstract The resting membrane potential of the pacemaker neurons is one of the essential mechanisms underlying rhythm generation. In this study, we described the biophysical properties of an uncharacterized channel (U-type channel) and investigated the role of the channel in the rhythmic activity of a respiratory pacemaker neuron and the respiratory behaviour in adult freshwater snail Lymnaea stagnalis. Our results show that the channel conducts an inward leak current carried by Na+ (ILeak-Na). The ILeak-Na contributed to the resting membrane potential and was required for maintaining rhythmic action potential bursting activity of the identified pacemaker RPeD1 neurons. Partial knockdown of the U-type channel suppressed the aerial respiratory behaviour of the adult snail in vivo. These findings identified the Na+ leak conductance via the U-type channel, likely a NALCN-like channel, as one of the fundamental mechanisms regulating rhythm activity of pacemaker neurons and respiratory behaviour in adult animals. Citation: Lu TZ, Feng Z-P (2011) A Sodium Leak Current Regulates Pacemaker Activity of Adult Central Pattern Generator Neurons in Lymnaea Stagnalis. PLoS ONE 6(4): e18745. doi:10.1371/journal.pone.0018745 Editor: Vladimir Brezina, Mount Sinai School of Medicine, United States of America Received December 15, 2010; Accepted March 9, 2011; Published April 19, 2011 Copyright: 2011 Lu, Feng. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, dist
您可能关注的文档
- a numerical approach to ion channel modelling using whole-cell voltage-clamp recordings and a genetic algorithm离子通道的数值方法模拟使用全细胞电压钳记录和遗传算法.pdf
- a one-step miniprep for the isolation of plasmid dna and lambda phage particles的一步miniprep隔离的质粒dna和λ噬菌体粒子.pdf
- a novel tumor-promoting function residing in the 5′ non-coding region of vascular endothelial growth factor mrna一种新型肿瘤促进功能的5u2032非编码区域居住在血管内皮生长因子mrna.pdf
- a one pot, one step, precision cloning method with high throughput capability一锅、一步、精密克隆方法和高吞吐量的能力.pdf
- a one-step real-time multiplex pcr for screening y-chromosomal microdeletions without downstream amplicon size analysis一步实时多重pcr筛选y-chromosomal微小缺失没有下游扩增子尺寸分析.pdf
- a nuclear localization of the infectious haematopoietic necrosis virus nv protein is necessary for optimal viral growth核本地化的传染性造血的坏死病毒nv蛋白质最佳病毒增长是必要的.pdf
- a p53-dependent response limits epidermal stem cell functionality and organismal size in mice with short telomeresp53-dependent反应限制了表皮干细胞功能和生物的大小在小鼠短的端粒.pdf
- a pair of dopamine neurons target the d1-like dopamine receptor dopr in the central complex to promote ethanol-stimulated locomotion in drosophila一对多巴胺神经元目标d1-like多巴胺受体dopr中部复杂促进果蝇ethanol-stimulated运动.pdf
- a pandemic influenza h1n1 live vaccine based on modified vaccinia ankara is highly immunogenic and protects mice in active and passive immunizations基于修改的h1n1大流行性流感活疫苗牛痘安卡拉高度免疫原性和保护老鼠在主动和被动免疫.pdf
- a paradox of syntactic priming why response tendencies show priming for passives, and response latencies show priming for actives一个悖论的句法启动为什么反应倾向显示启动被动者,和响应延迟启动活性物.pdf
- a sox2 bac transgenic approach for targeting adult neural stem cells一个sox2 bac转基因方法针对成人神经干细胞.pdf
- a spatial model of mosquito host-seeking behavior一个空间模型,蚊子host-seeking行为.pdf
- a spike-timing pattern based neural network model for the study of memory dynamicsspike-timing模式研究基于神经网络模型的动态内存.pdf
- a spectrum of pleiotropic consequences in development due to changes in a regulatory pathway光谱的多效性的后果,由于监管变化发展途径.pdf
- a splice isoform of dnedd4, dnedd4-long, negatively regulates neuromuscular synaptogenesis and viability in drosophiladnedd4拼接异构体,dnedd4-long负调节神经肌肉突触发生和果蝇生存能力.pdf
- a specialized odor memory buffer in primary olfactory cortex一个专门的气味在初级嗅觉皮层内存缓冲区.pdf
- a splice site variant in the bovine rnf11 gene compromises growth and regulation of the inflammatory response拼接网站牛rnf11基因变体妥协增长和调节炎症反应.pdf
- a spectrum of severe familial liver disorders associate with telomerase mutations光谱严重的家族性肝疾病与端粒酶突变.pdf
- a spiroligomer α-helix mimic that binds hdm2, penetrates human cells and stabilizes hdm2 in cell culture一个spiroligomerα-helix模拟,结合hdm2穿透人体细胞在细胞培养和稳定hdm2.pdf
- a sox10 expression screen identifies an amino acid essential for erbb3 functionsox10表达式屏幕识别所必需的一种氨基酸erbb3函数.pdf
文档评论（0）