a novel unsupervised method to identify genes important in the anti-viral response application to interferonribavirin in hepatitis c patients一种新颖的无监督方法来识别基因重要的抗病毒反应应用interferonribavirin丙型肝炎患者.pdfVIP

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a novel unsupervised method to identify genes important in the anti-viral response application to interferonribavirin in hepatitis c patients一种新颖的无监督方法来识别基因重要的抗病毒反应应用interferonribavirin丙型肝炎患者.pdf

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a novel unsupervised method to identify genes important in the anti-viral response application to interferonribavirin in hepatitis c patients一种新颖的无监督方法来识别基因重要的抗病毒反应应用interferonribavirin丙型肝炎患者

A Novel Unsupervised Method to Identify Genes Important in the Anti-viral Response: Application to Interferon/Ribavirin in Hepatitis C Patients 1 3 3 4 2 2 Leonid I. Brodsky , Abdus S. Wahed , Jia Li , John E. Tavis , Takuma Tsukahara , Milton W. Taylor * 1 Institute of Evolution, University of Haifa, Haifa, Israel, 2 Department of Biology, Indiana University, Bloomington, Indiana, United States of America, 3 Epidemiology Data Center, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, 4 Molecular Microbiology and Immunology, St. Louis University, St Louis, Missouri, United States of America Background. Treating hepatitis C with interferon/ribavirin results in a varied response in terms of decrease in viral titer and ultimate outcome. Marked responders have a sharp decline in viral titer within a few days of treatment initiation, whereas in other patients there is no effect on the virus (poor responders). Previous studies have shown that combination therapy modifies expression of hundreds of genes in vitro and in vivo. However, identifying which, if any, of these genes have a role in viral clearance remains challenging. Aims. The goal of this paper is to link viral levels with gene expression and thereby identify genes that may be responsible for early decrease in viral titer. Methods. Microarrays were performed on RNA isolated from PBMC of patients undergoing interferon/ribavirin therapy. Samples were collected at pre-treatment (day 0), and 1, 2, 7, 14 and 28 days after initiating treatment. A novel method was applied to identify genes that are linked to a decrease in viral titer during interferon/ribavirin treatment. The method uses the relationship between inter-patient gene exp