a sexual ornament in chickens is affected by pleiotropic alleles at hao1 and bmp2, selected during domestication性点缀在鸡是受效等位基因hao1 bmp2,选择在驯化.pdfVIP

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a sexual ornament in chickens is affected by pleiotropic alleles at hao1 and bmp2, selected during domestication性点缀在鸡是受效等位基因hao1 bmp2,选择在驯化.pdf

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a sexual ornament in chickens is affected by pleiotropic alleles at hao1 and bmp2, selected during domestication性点缀在鸡是受效等位基因hao1 bmp2,选择在驯化

A Sexual Ornament in Chickens Is Affected by Pleiotropic Alleles at HAO1 and BMP2, Selected during Domestication 1 1 2 3 4 Martin Johnsson , Ida Gustafson , Carl-Johan Rubin , Anna-Stina Sahlqvist , Kenneth B. Jonsson , 3 5 ¨ 3 2 1 1 Susanne Kerje , Olov Ekwall , Olle Kampe , Leif Andersson , Per Jensen , Dominic Wright * ¨ ¨ 1 IFM Biology, AVIAN Behavioural Genomics and Physiology Group, Linkoping University, Linkoping, Sweden, 2 Department of Medical Biochemistry and Microbiology, BMC, Uppsala University, Uppsala, Sweden, 3 Department of Medical Sciences, The Research Group of Autoimmunity, Akademiska Sjukhuset, Uppsala University, Uppsala, Sweden, 4 Department of Surgical Sciences, Orthopaedics, Akademiska Sjukhuset, Uppsala University, Uppsala, Sweden, 5 Department of Rheumatology and Inflammation Research, Institute of Medicine, The Sahlgrenska Academy, Gothenburg, Sweden Abstract Domestication is one of the strongest forms of short-term, directional selection. Although selection is typically only exerted on one or a few target traits, domestication can lead to numerous changes in many seemingly unrelated phenotypes. It is unknown whether such correlated responses are due to pleiotropy or linkage between separate genetic architectures. Using three separate intercrosses between wild and domestic chickens, a locus affecting comb mass (a sexual ornament in the chicken) and several fitness traits (primarily medullary bone allocation and fecundity) was identified. This locus contains two tightly-linked genes, BMP2