VEGF促进多孔聚乙烯耳支架植入效果观察.docVIP

VEGF促进多孔聚乙烯耳支架植入效果观察[摘要]目的：探讨VEGF对血管及软组织长入多孔聚乙烯支架的影响。方法：制作多孔聚乙烯支架置入动物体内的模型后，随机分成2组：第一组应用VEGF；第二组为对照组（不给任何药物）。术后第7天、第14天取出支架，做组织学分析观察毛细血管及肉芽组织长入状况。结果：应用VEGF组血管及肉芽组织长入孔隙迅速，而对照组长入缓慢，有显著性差异。结论：血管内皮生长因子可促进血管及软组织长入多孔聚乙烯支架，从而加强了该支架的稳定性，促进植入效果。 [关键词]耳支架；血管内皮生长因子（VEGF）；耳再造 [中图分类号]Q813[文献标识码]A[文章编号]1008-6455（2008）08-1178-03 The effects of VEGF on blood vessels and soft tissues growing into the porous polyethylene pivoting helix framework TIAN Li-liang1,DIAO Zhi-yong2 （1.Department of Plastic And Cosmetic Surgery, the Fifth Affiliated Hospital of harbin Medical University, Daqing 164300,Heilongjiang,China; 2. Department of Plastic and Cosmetic Surgery,the Fifth Affiliated Hospital of harbin Medical University,Harbin 150001,Heilongjiang，China） Abstract： ObjectiveTo observe the effects of VEGF on blood vessels and soft tissues growing into the porous polyethylene pivoting helix framework.MethodsPorous polyethylene pivoting helix frameworks were implanted into the rabbits’ bodies. The rabbits were randomly divided into two groups, VEGF group and the control group. The control groups were given nothing. The frameworks were taken out to observe the growth of blood vessels and soft tissues.ResultsThe results showed that blood vessels and granulation tissue grew into the pores rapidly in the VEGF group. However, blood vessels and granulation tissue grew into the pores of the control groups slowly. There was significant difference between the experimental groups and the control groups.ConclusionOur results suggest vascular endothelial growth factor promoted blood vessels and soft tissues growing into porous polyethylene pivoting helix framework. Thereby, VEGF was able to improve the effect of porous Polyethylene pivoting helix framework after it was implanted. Key words：ear framework；vascular endothelial growth factor（VEGF） 耳廓再造所选用的耳支架，以往多使用自体肋软骨雕刻而成，其优点是无排异反应，但手术对胸壁有创伤，取材受到一定限制，而将肋软骨雕刻成立体感强的耳廓支架亦有一定难度[1]。而应用异体肋软骨支架容易被吸收及变形[2-3]。硅橡胶支架及硅胶管钢丝支架则有很高的排异外露率[4]。我科自从1