阿魏酸哌嗪脉冲释药片的制备及其体外释药影响-中国现代应用药学.PDFVIP

·药 剂· 阿魏酸哌嗪脉冲释药片的制备及其体外释药影响因素考察 王乐，陈晶，边虹铮(河北化工医药职业技术学院制药工程系，石家庄 050026) 摘要：目的 以阿魏酸哌嗪为模型药物，考察制备脉冲给药系统的可行性。方法 制备含有阿魏酸哌嗪的片芯，在外层 进行乙基纤维素材料的包衣，制备脉冲释药片。通过体外释放度实验，考察片芯及包衣层处方对药物释放时滞的影响。 结果 片芯中崩解剂种类及用量、包衣层厚度、包衣层中致孔剂用量均对阿魏酸哌嗪脉冲释药片的释药行为有所影响。 结论 阿魏酸哌嗪脉冲释药片体外释放度试验中呈现良好的脉冲释药行为，并可通过调整崩解剂用量、包衣层厚度、包 衣层中致孔剂用量等因素调整其释药时滞。 关键词：阿魏酸哌嗪；脉冲释药；时滞 中图分类号：R944.4 文献标志码：B 文章编号：1007-7693(2012)04-0342-04 Preparation and in Vitro Study of Piperazine Ferulate Pulsatile-release Tablets WANG Le, CHEN Jing, BIAN Hongzheng(Department of Pharmaceutical Engineering, Hebei Chemical Pharmaceutical College, Shijiazhuang 050026, China) ABSTRACT: OBJECTIVE To investigate the preparation of pulsatile-release tablet of piperazine ferulate. METHODS The core tablet containing piperazine ferulate was first prepared and then coated with ethycellulose. Effect of core and coating layer was evaluated by dissolution test in vitro. RESULTS The kind of disintegrants, amount of disintegrant, amount of PEG6000, and coating weight of ethycellulose layer were demonstrated to influence the drug release of piperazine ferulate pulsatile-release tablet. CONCLUSION The pulsatile-release tablet of piperazine ferulate has been designed to release drug rapidly at the predetermined time. The release profile can be adjusted by the amount of disintegrant, amount of PEG6000 and the coating weight of ethycellulose layer. KEY WORDS: piperazine ferulate; pulsatitle release tablets; lag time 口服脉冲给药系统是以疾病发作的时辰药理 仪(天津大学无线电厂) ；UV-2450 紫外可见分光光 学特点为依据发展而成的新型给药系统。该制剂 度计( 日本岛津) ；TDP 单冲式压片机(上海第一制 选择在疾病治疗需要的时刻释放药物，避免患者 药机械厂) 。 在夜间服药，增加了患者的用药顺应性，亦可提 PF(武汉银河化工有限公司，批号：090801， 高药效，减少不良反应，适用于支气管哮喘、心 纯度：99.1%) ；乙基纤维素(EC 10cp，泰安瑞泰纤 肌梗死、心绞痛、风湿病、高血压等常见疾病的 维素公司) ；乳糖(德国