部分卵裂球损伤对冻融后胚胎发育潜能的影响.pdfVIP

· 26· 中国生育健康杂志2008年第 l9卷第1期 · 生 殖 医学 · 部分卵裂球损伤对冻融后胚胎发育 潜能的影响 郑晓英 刘平 吴昱琪 廉颖 乔杰 【摘要】 目的 了解部分卵裂球损伤对冻融后优质胚胎发育能力的影响，为解冻周期移植 胚胎的挑选提供依据。 方法 对502例解冻移植周期进行回顾性分析。所有移植胚胎分为两类， 胚胎冻融后所有卵裂球均无损伤，卵裂球数6，碎片10％ (A型)；冻融后胚胎有1～2个卵裂 球损伤，但仍有至少6个完整无损伤卵裂球，碎片10％ (B型)。无损伤组移植的所有胚胎均为 A型 (n=294周期)，部分损伤组移植胚胎中至少包含1个B型胚胎 (n=208周期)。比较2组临 床妊娠率和着床率。 结果 无损伤组临床妊娠率为36．73％ (108／294)，着床率19．42％ (153／ 788)，部分损伤组为38．46％ (80／208)和19．43％ (110／566)，2组临床妊娠率和着床率比较， 差异无统计学意义 (P0．05)。而且含1枚B型胚胎组 (163周期)和2枚B型胚胎组 (42周期) 的临床妊娠率和着床率比较，差异无统计学意义 (P0．05)。 结论 少量卵裂球损伤的冻融后 优质胚胎，其发育潜能与无损伤优质胚胎相同。 【关键词】 卵裂球损伤；胚胎冷冻；着床 Impact ofblastomeres loss on the viability ofthawed good—quality embryos ZHENGXiaoying LIU ， ， Yuqi，et a1．Dept．Ob ．Peking University，Third Hospital，Beqing 100083，China 【Al~traet】 Objective To assess the impact ofbl~tomeres loss on the viabihty ofthawed good—quality embryos． Mellm~ We analyzed 502 frozen thawed embryos replacement cycles retrospectively．AⅡtrans— ferred embryos were categorized into two types：type A was thawed embryos with all their ori na1 6～8 blasto— nle瑚 intact and less than 10％ fragmentation．Type B was partially damaged emb ryos which have 1～2 blast~ nllei~s loss but remained 6 intact bl~tomeres or greater and less than 10％ fragmentation．Outcomes offrozen em- bryo transfer cycles in which all embryos were type A(intact group，n=294)were compared with those in which transferred embryos included at least one type B(damaged group，n=208)． Results Intact group and dam- aged group we~fe comparable with respect to inean age at frozen transfer，endometrial thickness and No．of trans— fer~d emb ryos．No significant difference was found between the two groups with the clinical pregnancy rates and implantation rates(36．73％and 19．42％VS．38．