含左氧氟沙星四联方案补救治疗幽门螺杆菌52例临床研究.docVIP

含左氧氟沙星四联方案补救治疗幽门螺杆菌52例临床研究[摘要] 目的 探讨含左氧氟沙星四联方案在补救治疗幽门螺杆菌中的应用价值。 方法 选择消化性溃疡及慢性萎缩性胃炎患者102例，分为观察组和对照组，观察组患者应用雷贝拉唑、左氧氟沙星、阿莫西林及胶体果胶铋，对照组患者应用雷贝拉唑、阿莫西林、胶体果胶铋，治疗周期为14 d。 结果 治疗4周后，观察组中46例患者幽门螺杆菌阴性比例为88.5%，对照组中36例患者幽门螺杆菌阴性比例为72.0%，观察组患者幽门螺杆菌转阴率明显高于对照组（χ2 = 4.382 0，P = 0.036 3）。两组患者不良反应发生率间差异无统计学意义（χ2 = 0.572 5，P = 0.449 3）。 结论 含左氧氟沙星四联方案在补救治疗幽门螺杆菌中具有良好的效果。 [关键词] 左氧氟沙星；四联方案；幽门螺杆菌 [中图分类号] R573 [文献标识码] A [文章编号] 1673-7210（2012）07（b）-0052-02 Clinical analysis of quadruple therapy containing Levofloxacin in the remedial treatment of 52 cases with Helicobacter pylori HUANG Jun Department of Gastroenterology, the Third People’s Hospital of Hainan Province, Sanya 572000, China [Abstract] Objective To investigate the value of quadruple therapy containing Levofloxacin in the remedial treatment of Helicobacter pylori. Methods 102 patients with peptic ulcer and patients with chronic atrophic gastritis were divided into two groups, the observation group was treated with Rabeprazole, Levofloxacin, Amoxicillin and Colloidal Bismuth Pectin. Control group was treated with Rabeprazole, Amoxicillin and Colloidal Bismuth Pectin, the treatment cycle was 14 d. Results After treatment for 4 weeks, 46 cases of patients with Helicobacter pylori-negative in the observation group, the ratio was 88.5%, 36 cases of patients with Helicobacter pylori-negative control group, the proportion was 72.0%, the pyloric screw bacilli negative conversion rate of the observation group was significantly higher (χ2 = 4.382 0, P = 0.036 3). There was no significant difference between the adverse reaction rate of two groups (χ2 = 0.572 5, P = 0.449 3). Conclusion The quadruple therapy containing Levofloxacin has a good effect in the remedial treatment of Helicobacter pylori. [Key words] Levofloxacin; Quadruple therapy; Helicobacter pylori 幽门螺杆菌与多种胃肠道疾病相关，早期、准确的诊断和鉴别诊断对选择合理的治疗方法，改善患者预后具有十分重要的意义。由于细菌耐药性的增加，常规三联和四联疗法对幽门螺杆菌治疗的根除率降低。左氧氟沙星属于氟喹诺酮类抗生素，在多种细菌的治疗中有良好的效果，且耐药性相对较低[1]。本研究中，笔者通过对照研究，探讨含左氧氟沙星四联方案在补救治疗幽门螺杆