一种全新序列分类模型-WolframScience.pptVIP

A subsequent study of visualized DNA sequence comparison based on NKS Basic terms about DNA sequence 1. DNA is made up of nucleotides. 2. Nucleotides include ‘A’ ‘G’ ‘C’ ‘T’. 3. For same nucleotide compositions, different sequences show evidently different stability of DNA helix. For example, -GC- is much more stable than -CG-. 4. There may be some interaction between the nucleotides. Experimental approaches to study interaction between nucleotides Atomic force microscope (AFM) It is a very high-resolution type of scanning probe microscope, with demonstrated resolution of fractions of a nanometer. X-ray diffraction (XRD) The techniques are based on the elastic scattering of x-rays from structures that have long range order. Neutron scattering The deflection of neutron particles is used as a scientific probe Nuclear magnetic resonance (NMR) It is a physical phenomenon based upon the quantum mechanical magnetic properties of an atoms nucleus. Infrared spectroscopy (IR Spectroscopy) It is the subset of spectroscopy that deals with the IR region of the EM spectrum Questions Four DNA sequences: 1. CTCGGGTTATCGGCGTGGTCCGGCCGAGGGCGGCATTCCAGAAGAGGGACCCTCACGCCACCA 2. CCAGAGCGTCGCCGACCCTCTAATTGGTCTCCCCAGAAGAGGCTGAGAAGAAGGCCGAAACAG 3. AGAGTCCCAGGACACACTGTAGAAGATCAAAGCAGAAGAAGAGGGAAGAGTGGCTGAGGGAC 4. TCAGCCCATCTGCCATCCCCAAAGATAGAAGACACCCCCTTGGTTGCCCTCTAGAAGATCCAGT Can you figure out which organisms the sequences belong to? Is there any “inner-difference” between the sequences? Can you figure out what are the differences and interaction? The question has not been clarified successfully by the existing approaches based on traditional mathematical rules. Here ‘Wolfram approach’ can do something…. It may shape the current theory of DNA sequence analysis. Wolfram approach 1) The Wolfram approach is based on the concept that simple rules are able to produce highly co