微小剂量阿司匹林对高尿酸血症模型小鼠血尿酸的影响考察.pdfVIP

微小剂量阿司匹林对高尿酸血症模型小鼠血尿酸的影响考察 张海英17卓来东 ，李玉珍 (1．北京大学人民医院药剂科，北京市 100044；2．北京大学药学院，北京市 100083) 中图分类号 R965；R972 文献标识码 A 文章编号 1001—0408(2008)19—1482—03 摘 要 目的：考察微小剂量阿司匹林对高尿酸血症模型小鼠血尿酸水平等的影响。方法：75只小鼠随机分为5组，包括正常对照 组、高尿酸对照组和阿司匹林低、中、高实验组。对照组给予0、5％羧甲基纤维素钠溶液，实验组分别给予3种剂量(12．5、25、50 mg·kg-1)阿司匹林溶液，每天1次，持续l周后，除正常对照组外，其余4组腹腔注射尿酸溶液，建立高尿酸血症模型，并于建模 后l h取血样测定尿酸、肌酐和尿素氮水平。结果：与高尿酸对照组比较，各剂量阿司匹林对肌酐、尿素氮影响不明显，但可显著升 高血尿酸水平(P0．000 1)，但随剂量增加，血尿酸水平逐渐降低。结论：微小剂量阿司匹林可导致高尿酸血症模型小鼠血尿酸水 平升高，推测其作用机制可能与抑制尿酸排泄有关。 关键词 阿司匹林；高尿酸血症模型；小鼠；血尿酸；肌酐；尿素氮 Effect of Minidose Aspirin on Uric Acid in Hyperuricemia Model Mice ZHANG Hal—ying，LI Yu—zhen(Dept．of Pharmacy，People’s Hospital，Peking University，Beijing 100044， China) ZHUO Lai—dong(School of Pharmaceutical Sciences，Peking University，Beijing 100083，China) ABSTRACT OBJECTIVE：To evaluate the effects of minidose aspirin on blood uric acid，creatinine and urea nitrogen in hyperuricemia model mice．METHODS：75 mice were randomly assigned to receive 0．5％CMC—Na (normal control group and hyperuricemia control group)or aspirin (12．5，25，50 mg· ·d )q．d for 1 week．Then all the mice except the normal control group were intraperitoneal1y administered with uric acid to establish hyperuricemia mode1．1 h later，the blood sample was collected for determination of uric acid．creatinine and urea nitrogen．RESULTS：As compared with hyperuricemia control group，mini—dose aspirin had no apparent effect on creatinine and urea nitrogen，but remarkably increased the level of blood uric acid(P0．000 1)，and the level blood uric acid decreased in a dose—dependent manner．C0NCLUS10NS：Minidose asDirin can significantly increase blood uric acid level in hyperuricemia model mice，and this effect might attribute to its inhi— bition on the excretion of uric acid． KEY WoRDS Aspirin；Hyperuricemia model；Mice；Blood uric acid；Creatinine；Urea nitrogen 阿司匹林对尿酸代谢具有双重作用，Yu等 ‘引在1959年 显升高，而随给药剂量增加到150、325 mg·d 时，血尿酸水 和1963年进