progress on post-translational histone acetylation - 临床与病理杂志.pdfVIP

临床与病理杂志 2015, 35(8) J Clin Path ol R e s 1579 doi: 10.3978/j.issn.2095-6959.2015.08.029 View this article at: /10.3978/j.issn.2095-6959.2015.08.029 翻译后组蛋白乙酰化与骨代谢的研究进展 邓展涛，金洁雯 综述 徐海栋，赵建宁 审校 (南京大学医学院附属金陵医院(南京军区南京总医院)骨科，南京 210002) [摘　要] 表观遗传学是指研究基因的核苷酸序列不发生改变的情况下，基因表达的可遗传的变化的一门 遗传学分支学科，主要包括 miRNA 介导的转录后调控、翻译后的组蛋白修饰以及 DNA 甲基化。 其中，组蛋白乙酰化作为组蛋白修饰中研究最广的内容，已经被证实能影响多种生理以及病理过 程。在骨代谢中，组蛋白乙酰化影响着成骨细胞和破骨细胞的分化成熟，在骨形成和骨吸收动态 平衡中起着至关重要的作用。本文综述了组蛋白乙酰化对骨代谢的影响，以及各种组蛋白乙酰化 酶 (histone deacetylase ，HATs) 和组蛋白去乙酰化酶(histone deacetylase ，HDACs)在其中的作用，希 望为下一步探讨组蛋白乙酰化对骨代谢相关疾病的影响提供方向。 [关键词] 组蛋白乙酰化；成骨细胞；破骨细胞；组蛋白去乙酰化酶；组蛋白去乙酰化酶；SIRT1 Progress on post-translational histone acetylation in bone metabolism DENG Zhantao, JIN Jiewen, XU Haidong, ZHAO Jianning (Department of Orthopedics, Jinling Hospital, Nanjing University School of Medicine, Nanjing General Hospital of Nanjing Military Region, PLA, Nanjing 210002, China) Abstract Epigenetics is the study of mechanisms able to influence gene expression in heritable manner without altering the DNA sequence. These mechanisms include miRNA-mediated post-transcriptional regulation, post-translational histone modifications and DNA methylation. Among all the histone modification, histone acetylation is reserched most widely. And it has been confirmed to influence many physiological and pathological progresses. In bone metabolism, histone acetylation influences osteoblastogenesis and osteoclastogenesis. Thus, it plays an important role in bone homeos