山东泰莱地区胃恶性肿瘤发生与ABO血型的相关性研究.pdfVIP

实用医药杂志2008年o3月第25卷第o3期 Prac J Med＆Pharm．Vol 25．2008—03 No．0 预防医学·卫生学 山东泰莱地区胃恶性肿瘤发生 ．论著． 与ABO血型的相关性研究 李大鹏① 靳 丽① 刘文清① 任 红① 康俊升① 李 静② 王锦庆① (@88医院检验科，山东泰安 271000；(~-／2253部队门诊部，山东济南 250002) 【摘 要】 目的 研究胃恶性肿瘤发生与ABO血型抗原分布关系。方法 选择 东泰安及莱芜地区胃恶 性肿瘤患者686例．采用血型群体遗传学及血型血清学方法，进行ABO血型表现型及基因频率分布调查 统计。结果 发生胃恶性肿瘤的ABO血型抗原分布与对照组存在 著性差异( 0．05)。结论 提示发生 胃恶性肿瘤与患者ABO血型问有显著相关性关系，血型I大I素足重要的胃恶性肿瘤易感因素。 【关键词】 胃恶性肿瘤 ABO血型 血型抗原 【中图分类号】R735．2：R457．1 l 【文献标识码】A Study on the correlativity of ABO blood type of the patients from the Tai—．Lai regions of Shandong province with their stomach neoplasms etiology LI Da—peng~,JIN Li，LIU Wen-qing，et a1．~The Central Medical Laboratorythe 88th Hospital of PLA，Taian 271000，China ， 【Abstract] Objective To study the relativity between etiology of stomach carcinoma and ABO blood type antigen distribution．Methods ABO phenotype and their gene frequency distribution were investigated in 686 patients from the center south region of Shandong province by using blood type population genetics and serology assay．Results The significant difference in ABO blood type antigen distribution was found between the patients with carcinoma of stomach and the controls(PO．05)，i．e． there was Some significant correlativity between the probability suffering from the disease and ABO blood type．Conclusion There is significant correlativity between etiology of stomach carcinoma and ABO blood type，SO blood type is an susceptible factor that leads to carcinoma of stomach． 【Key words] Carcinoma of stomach ABO blood type Blood type antigen 在我国，胃癌居各类恶性肿瘤死冈的首位，对 为对照组，性别不限，排除恤缘关系。 胃癌癌变机制的深入研究和预防是肿瘤研究的重 1．2 m型血清学检测方法 血型检测m样本为采 要课题【l1。胃恶性肿瘤的发生受遗传因素、环境因 集新鲜 样，方法按文献【2】。选择Bemst