自噬在哺乳动物卵巢黄体功能维持及其退化过程中的作用.pdf

中国细胞生物学学报 Chinese Journal of Cell Biology 2017, 39(5): 681–686 DOI: 10.11844/cj cb.2017.05.0014 自噬在哺乳动物卵巢黄体功能维持 及其退化过程中的作用 唐宗浩 张正红 唐业东 王正朝* (福建师范大学生命科学学院, 福建省发育与神经生物学重点实验室, 福州350007) 摘要 自噬是一种广泛存在于真核细胞中的分解代谢过程, 在饥饿、缺氧等应激条件下细胞 可以通过自噬途径降解自身组分来维持细胞的内稳态以及物质代谢的平衡, 从而使细胞存活。黄 体作为哺乳动物卵巢中的暂时性组织结构, 对维持卵巢功能及早期妊娠具有非常重要的作用, 其主 要功能之一是合成孕酮。目前的研究表明, 自噬参与了妊娠黄体功能的维持, 并促进黄体退化过程 中的细胞凋亡。该文对自噬在哺乳动物卵巢黄体功能维持及其退化过程中的作用进行综述, 旨在 为进一步研究哺乳动物卵巢黄体功能的调控机制提供重要的参考资料。 关键词 自噬; 黄体退化; 细胞凋亡; 孕酮 Contribution of Autophagy to the Maintenance of Luteal Functions and the Regression of Corpus Luteum in the Mammalian Ovary Tang Zonghao, Zhang Zhenghong, Tang Yedong, Wang Zhengchao* (Provincial Key Laboratory for Developmental Biology and Neurosciences, College of Life Sciences, Fujian Normal University, Fuzhou 350007, China) Abstract Autophagy is a catabolic process widely existed in the eukaryocytes. Under starvation or oxidative stress, cells may degradate their components and recycle them via autophage to maintain intracellular homeostasis and metabolic balances for the survival of cells. Corpus luteum is an ephemeral endocrine gland in the mammalian ovary, playing a pivotal role in the maintenance of luteal functions and early pregnancy. The production of progesterone is one core function of corpus luteum in the ovary. Present researches have demonstrated that autophagy is involved in the maintenance of luteal functions during the pregnancy and boost the apoptosis of luteal cells during the regression. Therefore, the contribution of autophagy to the maintenance of luteal functions and the regression of corpus luteum in the mammalian ovar