中国肾小球滤过率评估方程应用于老年慢性肾脏病患者评价_刘迅.pdfVIP

·370 · 　2009 8 23 4 　　Chin J School Doctor　A g.2009　Vol.23　No.4　 [] 　1001-7062(2009)04-0370-04　[] 　R 692.6　[] 　A [] ＊ 刘迅,王成, 唐骅, 陈珠江,彭晖, 娄探奇 　　[] 　　评价现有在中国人群基础上开发的肾小 滤过率(GFR)评估方程对老年慢性肾脏病(CKD) 患者的适用性。 　　选择103 例老年CKD 患者,用中国方程、瑞金方程分别预测GFR 值, 与体表面积标准化 99mTc DTPA 测的GFR(sGFR)进行比较。 　　Bland-Altman 分析显示瑞金方程估计的 GFR 和 sGFR 的一 致性最好, 但所有方程估计的GFR 和sGFR 的一致性限度均超过事先规定的专业界值。线性回归结果显示, 瑞金 方程估测的GFR 与X 轴的斜率比其他方程更小。瑞金方程、MDRD 1 方程和中国5 方程估测 GFR 15%符合率、 30%符合率和50%符合率均较高, 但所有方程估测GFR 30%符合率依然低于70%。在 CKD 的不同分期中, 瑞金 方程和MDRD 1 方程估测GFR 15%符合率、30%符合率和50%符合率均较高。 　　当血肌酐的测定方法为 酶法时, 如果直接应用目前在中国人群基础上开发出的 GFR 评估方程预测老年CKD 患者的GFR, 可能会产生明 显的偏差。 []　肾疾病;肾小 滤过率;评价研究 Application of Chinese modified glomerular filtration rate estimation equations in elder- ly patients with chronic kidney diseases　　LIUX un, WAN G Cheng, TAN G Hua, et al.Nep hrology Dep artment of Internal Medicine, The Third Aff iliated Hosp ital of hongshan University, Guangzhou 510630, Guangdong, China [Abstract] 　Objective 　To eval ate the applicability of modified form las based on plasma creatinine levels in elderly Chinese patients with chronic kidney diseases (CKD).　Methods 　A total of 103 elderly CKD patients were investigated. Glomer lar filtration rate (GFR)was estimated w ith Chinese eq ations and the R ijin eq ation.The acc racy of estimat- ed sGFR w as compared with 99mTc-DTPA-GFR in elderly CKD patients.　Results　Bland-Altman analysis demonstrat- ed that the R ijin eq ation was more consistent with sGFR than the other eq ations.How ever, all the eq ations were not well consistent with sGFR.Linear regressions show ed that the slope of the R ijin eq ation was closer to the identical line. The 15%, 30%and 50%acc racies of the R ijin