B7_H3及其与肿瘤关系的研究进展.pdfVIP

! 34 30! 2009 11 15 22 M ed ical R ecap i u la e, N ov 2009, V o.l 15, N o. 22 B7H3 * 赵文健 , 陈春燕 , 眭文妍 ( ) , 罗招阳 ( ) ( , 42 1001) : R73 : A : ( 2009) : B7 同源性 3( B7H3 ) 是 200 1年新发现的 B7家族成员B7H 3 mRNA 广泛表达在人体各种 组织中其受体可能是髓样 胞触发受体家族的成员TLT 2B7H 3分子的确切作用及其机制尚不确 B30. 1 定, 可能存在双重作用, 即共刺激作用和( 或)共抑制作用研究发现, B7H 3蛋白在很多肿瘤组织中高 B7H 3 表达, 并与肿瘤的多种生物学特征密切相关目前认为 B7H 3 是一种新的肿瘤标志物和潜在的治疗 靶点 : B7H 3; 肿瘤; 生物学 B7H 3 Advancem ent on B7H3 and Its Relation w ith Tumors ZHAO W enj ian, CHEN Chunyan, SUI Wenyan, , L UO Zha oyang. (Cancer Research Institute of Uni ersity of S ou th Ch ina, H engyang 42 100 1, Ch ina) B7 Abstract: B7H 3, a new m emb er of he B7 fam ily, w as iden ified in 200 1. T he expression of B7H 3 mRNA is found o be w idely d is ribu ed in varie y of issu es. T rem L ik eT ran scrip 2( TLT 2 ), w h ich is a m emb er of he , B7 T riggering recep or expressed on M onocy e. H ow ever, h e ex ac fun c ion and m echan ism of B7H 3 are s il l un clear. T he mi m unologic func ion of B7H 3 rem ains con roversial, w i h conf lic ing cos mi u la ory and coinh ib i ory H 3 4 fun c ion s. R ecen s udies reveal ha B7H 3 pro ein is overexpressed in m any m alignancies and is closely rela ed , o b iological charac eris ics of um ors. T hus, B7H 3 rep resen s a novel d iagnos icm arker and po en ial herap eu ic arge for can cers. Key words: B7H 3; T um or; B iology