CNS淋巴瘤病变.pdf

Clinical Radiology 71 (2016) 602e609 Contents lists available at ScienceDirect Clinical Radiology journal homepage: Pictorial Review Lymphomatous involvement of the central nervous system G. Bathla a, A. Hegde b, * a Department of Radiology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA, USA b Department of Radiology, Raffl es Hospital, 585 North Bridge Drive, Singapore 188770, Singapore article information Lymphoma may arise within the central nervous system (CNS), known as primary CNS lym- Article history: phoma (PCNSL) or may involve the CNS secondary to systemic disease. Clinical features are Received 1 July 2015 non-specific. A provisional diagnosis of PCNSL can be made on imaging, potentially changing Received in revised form the management algorithm from neurosurgical resection to biopsy. PCNSL in immunocom- 21 January 2016 petent patients generally presents late, is solid, is bright on diffusion weighted imaging and Accepted 10 February 2016 shows uniform enhancement. Contiguity with a cerebrospinal fluid (CSF) surface and peri- vascular enhancement are useful clues. Immunocompromised patients, on the other hand, present earlier and often have multiple, necrotic, haemorrhagic lesions with irregular or rim enhancement. Secondary CNS involvement predominantly affects the leptomeninges. This