期刊In vitro and in vivo degradation profile of aliphatic polyesters subjected to electron beam sterilization.pdfVIP

Acta Biomaterialia 7 (2011) 2035–2046 Contents lists available at ScienceDirect Acta Biomaterialia journal homepage: /lo cate/actabiomat In vitro and in vivo degradation profile of aliphatic polyesters subjected to electron beam sterilization S. Dånmark a,b, A. Finne-Wistrand b, K. Schander a, M. Hakkarainen b, K. Arvidson a, K. Mustafa a, A.-C. Albertsson b,⇑ a Centre for Clinical Dental Research, Department of Clinical Dentistry, Faculty of Medicine and Dentistry, University of Bergen, Norway b Department of Fibre and Polymer Technology, School of Chemical Science and Engineering, Royal Institute of Technology, Sweden a r t i c l e i n f o a b s t r a c t Article history: Degradation characteristics in response to electron beam sterilization of designed and biodegradable Received 8 December 2010 aliphatic polyester scaffolds are relevant for clinically successful synthetic graft tissue regeneration. Received in revised form 13 January 2011 Scaffold degradation in vitro and in vivo were documented and correlated to the macroscopic structure Accepted 7 February 2011 and chemical design of the original polymer. The materials tested were of inherently diverse hydropho- Available online 26 February 2011 bicity and crystallinity: poly(L-lactide) (poly(LLA)) and random copolymers from L-lactide and e- caprolactone or 1,5-dioxepan-2-one, fabricated into porous and non-porous scaffolds. After s