期刊Radiation sterilization of fluoroquinolones in -olid state- Investigation of effect of gamma radiation and electron beam.pdfVIP

ARTICLE IN PRESS Applied Radiation and Isotopes 68 (2010) 1627–1635 Contents lists available at ScienceDirect Applied Radiation and Isotopes journal homepage: /locate/apradiso Radiation sterilization of fluoroquinolones in solid state: Investigation of effect of gamma radiation and electron beam Babita K. Singh a,c,n, Dilip V. Parwate a, Indrani B. Dassarma b, Sudhir K. Shukla c a Department of Chemistry, RTM Nagpur University Campus, Amravati Road, Nagpur 440033, India b Jhulelal Institute of Technology, Nagpur, India c Central Forensic Science Laboratory, Ramanthapur, Hyderabad 500013, India a r t i c l e i n f o a b s t r a c t Article history: The effect of gamma radiation from 60Co source and 2 MeV electron beam was studied on two Received 1 January 2009 fluoroquinolone antibiotics viz norfloxacin and gatifloxacin in the solid state. The changes in reflectance Received in revised form spectrum, yellowness index, vibrational characteristics, thermal behavior, UV spectrum, chemical 28 January 2010 potency (HPLC) and microbiological potency were investigated. ESR measurement gave the number of Accepted 5 April 2010 free radical species formed and their population. The nature of final radiolytic impurities was assessed by studying the HPLC impurity profile. Both norfloxacin and gatifloxacin were observed to be radiation Keywords: