白藜芦醇对梗阻性黄疸肠黏膜上皮屏障及氧化应激损伤的保护作用研究.pdf

目 录 中文摘要……………………………………………………………………l 英文摘要……………………………………………………………………9 英文缩写……………………………………………………………………18 论文题目 梗阻性黄疸肠黏膜上皮屏障损伤机制及白藜芦醇对其保护作用研究 00000………………………………………………20 引言………………0 第一部分恶性梗阻性黄疸患者小肠黏膜上皮细胞紧密连接蛋白表达改变 及意义 前言…………………………···………………………………………22刖吾一”””“”””””一”“”””““”一””一”一“”“一”””““一””“”2Z 材料与方法……………………………………………………………23 结果·············································…·················…··········29 附l訇··············································································3l 附表……………………………………………………………………34 讨论··············-·······························································35 小结··················…························…······························37 参考文献………………………………………………………………38 第二部分恶性梗阻性黄疸患者肠黏膜氧化应激损伤中血红素加氧酶．1表 达增加 前言”一”···”·······…···…·一…············…”…一·一””一”“一””一“4。0一刚吾”一”””””“”““”””一”“””””””””…一””””“一”””””‘ 材料与方法……………………………………………………………40 结果……······…···…………………···…………···………······……42 附图··············································································44 讨论··············································································48 小结·······································…······000900·····················．r··50 参考文献………………………………………………………………51 第三部分白藜芦醇对实验性梗阻性黄疸大鼠肠黏膜上皮屏障及氧化应激 损伤的保护作用 前言·········…···……………………···……………………······……52日IJ舌一”““”””“””“””””””””一””“”””””””“一“”一“”“”’Z 材料与方法……………………………………………………………53 结果··················…·······…······································…······64 ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● 7O ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● oo5