【2.1】2012年发表2006-2010年隐球菌病监测情况——哥伦比亚.pdfVIP

Biomédica 2012;32:386-98 Biomédica 2012;32:386-98 doi: /10.7705/biomedica.v32i3.707 ARTíCULO ORIGINAL Cryptococcosis in Colombia: Results of the national surveillance program for the years 2006-2010 Patricia Escandón1, Catalina de Bedout2, Jairo Lizarazo3, Clara Inés Agudelo1, ángela Tobón2, Solmara Bello1, ángela Restrepo2, Elizabeth Casta?eda1 y Grupo Colombiano para el Estudio de la Criptococosis4 1 Grupo de Microbiología, Instituto Nacional de Salud, Bogotá, D.C., Colombia 2 Corporación para Investigaciones Biológicas, Medellín, Colombia 3 Hospital Universitario Erasmo Meoz, Cúcuta, Colombia 4 Grupo Colombiano para el Estudio de la Criptococosis Introduction: A survey on cryptococcosis is being conducted regularly in Colombia since 1997. We present hereby the results corresponding to patients diagnosed from 2006 to 2010. Objective: To analyze the data obtained during this period. Materials and methods: Retrospective analysis of the corresponding surveys. Results: A total of 526 surveys originating from 72% of the Colombian political divisions were received during the 5-year period. Most patients (76.6%) were males and 74.9% were 21-50 years old. The most prevalent risk factor was HIV infection (83.5%) with cryptococcosis defining AIDS in 23% of the cases. In the general population the estimated mean annual incidence rate for cryptococcosis was 2.4 x 106 inhabitants while in AIDS patients this rate rose to 3.3 x 103. In 474 surveys stating clinical features, most frequent complaints were headache 84.5%, fever 63.4%, nausea and vomiting 57.5%, mental alterations 46.3%, meningeal signs 33.0%, cough 26.4% and visual alterations 24.5%. Neurocrypt