4 348-350 基础研究3 20091124人参茎叶总皂苷对心理应激荷瘤小肿瘤生长及化疗效果的影响4116A.pdf

现代食品科技 Modern Food Science and Technology 2010, Vol.26, No.4 人参茎叶总皂苷对心理应激荷瘤小鼠肿瘤生长 及化疗效果的影响 张晓文1，宋清2，徐志伟3 （1.广州市体育科学研究所功能学评价研究室，广东广州 510650）（2.广州体育职业技术学院，广东广州 510650）（3.广州中医药大学基础医学院，广东广州 510405) 摘要：探讨了人参茎叶总皂苷(GSLS)对心理应激状态荷瘤小鼠肿瘤的生长及化疗效果的影响。对C57/BL小鼠移植性肿瘤 Lewis肺癌鼠施以6 h/日束缚模拟心理应激，测定GSLS对小鼠肿瘤抑制率和对免疫器官质量的影响以及对化疗药环磷酰胺（CTX）治疗效果的影 响。结果 束缚应激组小鼠与对照组比较，??瘤质量增加40.82%(P0.01)，表明束缚应激状态下肿瘤生长明显；GSLS 100 mg/kg、200 mg/kg组与CTX联用组瘤重明显低于NS+束缚模型对照组(P0.05- 0.01)，表明GSLS与化疗联用组肿瘤抑制率明显提高。GSLS+束缚应激组胸腺和脾脏质量分别增加13.41%、7.06%，表明GSLS 对免疫器官有增重作用。人参茎叶总皂苷与化疗药物联用后对束缚应激状态的动物移植肿瘤有明显抑制作用，其可明显增强化 疗药物对肿瘤的抑制效应，机制可能与其抗心理应激、增强免疫及抗肿瘤的综合作用有关。 关键词: 人参茎叶总皂苷；抗肿瘤；心理应激 文章篇号：1673-9078(2010)4-348-350 Influences of Ginseng Stem and Leave Saponin on Tumor Growth of Tumor-bearing Mouse in Psychological Stress Status and the Chemo- therapy Effect ZHANG Xiao-wen1, SONG Qing2, XU Zhi-wei3 (1.Department.of Functional Evaluation,Guangzhou Institute of Sports Science,Guangzhou 510650, China) (2.Guangzhou Professional Technique College of Sports, Guangzhou 510650, China) (3.Department. of Basic theory of Traditional Chinese Medicine, Guangzhou University of Chinese Traditional Medicine, Guangzhou 510405, China.) Abstract: The influences of Ginseng Stem and Leave Saponin (GSLS) on tumor growth and immune function of Lewis lung cancer-bearing C57/BL mice were investigated. The tumor-bearing C57/BL mice were treated by the binding stress and then the effects of GSLS on tumor growth of the mice and chemotherapy effect were assayed. Immune organ spleen and the thymus gland weight were also measured. Results showed that, compared with control group,