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Development and Comparison of Automated Classifiers for Glaucoma Diagnosis Using Stratus Op.pdf

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Development and Comparison of Automated Classifiers for Glaucoma Diagnosis Using Stratus Op

Development and Comparison of Automated Classifiers for Glaucoma Diagnosis Using Stratus Optical Coherence Tomography Mei-Ling Huang1 and Hsin-Yi Chen2 PURPOSE. To develop and compare the ability of several auto- mated classifiers to differentiate between normal and glauco- matous eyes based on the quantitative assessment of summary data reports from Stratus optical coherence tomography (OCT; Carl Zeiss Meditec Inc., Dublin, CA) in a Chinese population in Taiwan. METHODS. One randomly selected eye from each of 89 patients with glaucoma and each of 100 age- and sex-matched normal individuals were included in the study. Measurements of glau- coma variables (retinal nerve fiber layer thickness and optic nerve head analysis results) were obtained by Stratus OCT. With the Stratus OCT parameters used as input, receiver oper- ative characteristic (ROC) curves were generated by three methods, to classify eyes as either glaucomatous or normal: linear discriminant analysis (LDA), Mahalanobis distance (MD), and artificial neural network (ANN). The area under the ROC curve was optimized by principal component analysis (PCA). Classification accuracy was determined by cross validation. RESULTS. The average visual field mean deviation was 0.7 0.6 dB in the normal group and 2.7 1.9 dB in the glaucoma group. The areas under the ROC curves were 0.824 (LDA), 0.849 (MD), 0.821 (ANN), 0.915 (LDA with PCA), 0.991 (MD with PCA), and 0.874 (ANN with PCA). CONCLUSIONS. With Stratus OCT parameters used as input, au- tomated classifiers show promise for discriminating between glaucomatous and normal eyes. MD measured from multivari- ate data can predict the severity of glaucoma through the construction of a measurement space. After PCA, implementa- tion results show that the Mahalanobis space created by MD surpasses LDA and ANN in diagnosing glaucoma. (Invest Oph- thalmol Vis Sci. 2005;46:4121–4129) DOI:10.1167/iovs.05- 0069 Alteration in the structural appearance of the optic nervehead