Dynamic contact angle cycling homogenizes heterogeneous surfaces.pdfVIP

Dynamic contact angle cycling homogenizes heterogeneous surfaces.pdf

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Dynamic contact angle cycling homogenizes heterogeneous surfaces.pdf

Materials Science and Engineering C 69 (2016) 1192–1200 Contents lists available at ScienceDirect Materials Science and Engineering C j ourna l homepage: www.e lsev ie r .com/ locate /msecDynamic contact angle cycling homogenizes heterogeneous surfacesR. Belibel, C. Barbaud ?, L. Mora INSERM U1148, Laboratory for Vascular Translational Science (LVTS), Institut Galilée, Université Paris 13, Sorbonne Paris Cité, 99 Avenue Jean-Baptiste Clément, Villetaneuse F-93430, France? Corresponding author. E-mail address: barbaud@univ-paris13.fr (C. Barbaud) /10.1016/j.msec.2016.08.013 0928-4931/? 2016 Elsevier B.V. All rights reserved.a b s t r a c ta r t i c l e i n f oArticle history: Received 18 May 2016 Received in revised form 12 July 2016 Accepted 4 August 2016 Available online 5 August 2016In order to reduce restenosis, the necessity to develop the appropriate coatingmaterial of metallic stent is a chal- lenge for biomedicine and scientific research over the past decade. Therefore, biodegradable copolymers of poly((R,S)-3,3 dimethylmalic acid) (PDMMLA) were prepared in order to develop a new coating exhibiting dif- ferent custom groups in its side chain and being able to carry a drug. This material will be in direct contact with cells and blood. It consists of carboxylic acid and hexylic groups used for hydrophilic and hydrophobic char- acter, respectively. The study of this material wettability and dynamic surface properties is of importance due to the influence of the chemistry and the potential motility of these chemical groups on cell adhesion and polymer kinetic hydrolysis. Cassie theory was used for the theoretical correction of contact angles of these chemical het- erogeneous surfaces coatings. Dynamic Surface Analysis was used as practical homogenizer of chemical hetero- geneous surfaces by cycling duringmany cycles inwater. In thiswork,we confirmed that, unlike receding contact angle, advancing contact angle is influenced by the difference of only 10% of acidic

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