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Controlled drug release from hydrogels for contact lenses Drug partitioning and diffusion.pdf

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Controlled drug release from hydrogels for contact lenses Drug partitioning and diffusion.pdf

International Journal of Pharmaceutics 515 (2016) 467–475 Contents lists available at ScienceDirect International Journal of Pharmaceutics journal homepage: /locate/ijpharm Controlled drug release from hydrogels for contact lenses: Drug partitioning and diffusion A.F.R. Pimentaa,b, J. Ascensoa, J.C.S. Fernandesa, R. Cola?ob, A.P. Serroa,c, B. Saramagoa,* a Centro de Química Estrutural, Instituto Superior Técnico, University of Lisbon, Av. Rovisco Pais, 1049-001 Lisbon, Portugal b IDMEC, Departmento de Engenharia Mecanica, Instituto Superior Técnico, University of Lisbon, Av. Rovisco Pais, 1049-001 Lisbon, Portugal c Centro de Investiga??o Interdisciplinar Egas Moniz, Instituto Superior de Ciências da Saúde Egas Moniz, Quinta da Granja, Monte de Caparica, 2829-511 Caparica, Portugal ARTICLE INFO Article history: Received 24 June 2016 Received in revised form 21 October 2016 Accepted 22 October 2016 Available online 24 October 2016 Chemical compounds studied in this article: Chlorhexidine diacetate monohydrate (PubChem CID: 9562059) Levo?oxacin (PubChem CID: 149096) Diclofenac sodium (PubChem CID: 5018304) Poly-hydroxyethylmethacrylate (PubChem CID: 13360) 3-Tris(trimethylsilyloxy)silylpropyl 2methylprop-2-enoate (PubChem CID: 123371) Poly(vinylpyrrolidone) (PubChem CID: 6917) Keywords: Drug release Contact lens Hydrogel membrane Partition coef?cient Diffusion coef?cient ABSTRACT Optimization of drug delivery from drug loaded contact lenses assumes understanding the drug transport mechanisms through hydrogels which relies on the knowledge of drug partition and diffusion coef?cients. We chose, as model systems, two materials used in contact lens, a poly-hydroxyethylmethacrylate (pHEMA) based hydrogel and a silicone based hydrogel, and three drugs with different sizes and charges: chlorhexidine, levo?oxacin and diclofenac. Equilibrium partition coef?cients were determined at different ionic strength and pH, using water (pH 5.6) and PBS (pH 7.4). The measured partition c