基于MATLAB的微循环数值分析———毛细血管几何特性对氧输送.PDFVIP

医用生物力学 　第 24 卷 　第 4 期 　2009 年 8 月 Journa l of M ed ica l B iom echan ics, Vol. 24　No. 4, A ug. 2009 263 文章编号 : 1004 7220 (2009) Num er ica l ana ly sis of the effect of cap illary geom etry on oxygen tran sport in the m icroc ircula tion by M ATLAB ZHU Kai, 　H E Ying (D ep a rtm en t of M odern M echan ics, Un ivers ity of S cience and Technology of Ch ina M a il B ox 4, H ef ei 230027) A b stract: O bjective　D elivery of oxygen in tissue s is lim ited in the sp ace where oxygen m u st d iffu se between the va scu lar and the surrounding tissue s. Norm al cap illarie s are relatively straigh t and well sp aced, in con tra st, the tumor va scu lar net work s u sually d isp lay more irregu larity and the ve ssel wall show s h igher p erm eab ility and le ss ela sticity. The pu rpo se of th is study wa s to inve stigate the effect of cap illary ela sticity and tortuo sity on the oxygen distribu tion and m ake fu rther inve stigation on the m echan ism of the form ation of hypoxic region s in tumor. M ethod　Onedim en sional cap illary model wa s coup led w ith the oxygen d iffu sion model. Oxygen tran sport wa s inve stigated in a Krogh and tortuou s tissue model. The cap illary geom etry wa s ob tained by the onedim en sional model and tran sferred to the tissue model. Fin ite elem ent m ethod wa s emp loyed in the a nalysis. Re sult　The cap illary rad ii along the flow d irection under p re ssu re s were ob tained for differen t in itial radii and the oxygen distribu tion in the Krogh cylinder tissue model and the model w ith a tortuou s cap illary were comp u ted. Conclu sion s　 when the cap illary radiu s is sm all, the effect of ve ssel ela stic