Preparation and in vitro anticancer activity comparison of photosensitive nanoparticles with different self-assemble degree》.pdfVIP

Dyes and Pigments 122 (2015) 206e212 Contents lists available at ScienceDirect Dyes and Pigments journal homepage: /locate/dyepig Preparation and in vitro anticancer activity comparison of photosensitive nanoparticles with different self-assemble degree Enyi Chen a, Xiaoli Mo b, Xuefeng Ge a, Ao Wang a, Shaohua Wei a, Lin Zhou a, *, Jiahong Zhou a, **, Jian Shen a a College of Chemistry and Materials Science, Analysis and Testing Centre, Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials, Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing 210023, China b College of Life Science, Nanjing Normal University, Nanjing 210023, China a r t i c l e i n f o a b s t r a c t Article history: Self-assembled organic photosensitive nanoparticles have been widely used in diagnosis and therapeutic Received 20 April 2015 of cancer. In this manuscript, a simple but effective method to regulate the self-assemble degree of small Received in revised form charge photosensitive drug was demonstrated. Studies indicated that the ordered self-assembled 26 June 2015 nanostructures with proper assemble degree can significantly enhances the reactive oxygen species Accepted 27 June 2015 generation efficiency and, thereby, improve the in vitro photodynamic efficacy comparing with the Available online 3 July 2015