Persistent osteopenia in adolescent idiopathic scoliosis (AIS) – Factors predisposing to generalized osteopenia, a cross-sectional and longitudinal investigation》.pdfVIP

International Congress Series 1297 (2007) 25 – 31 Persistent osteopenia in adolescent idiopathic scoliosis (AIS) – Factors predisposing to generalized osteopenia, a cross-sectional and longitudinal investigation Warren T.K. Lee a,b,⁎, C.S.K. Cheung a , Y.K. Tse c , W.W. Chau a , L. Qin a , Jack C.Y. Cheng a a Department of Orthopaedics Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong b Centre of Nutrition and Food safety, School of Biomedical and Molecular Sciences, University of Surrey, Guildford, Surrey, U.K. c Centre for Epidemiology and Biostatistics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Abstract. Generalized osteopenia in adolescent idiopathic scoliosis is well documented. No large- scale cross-sectional or longitudinal study has been conducted to determine factors contributing to low bone-mineral-density (BMD) and whether low BMD is persistent throughout adolescence. We aimed to determine the link between BMD, physical growth, calcium intake and bone turnover in 594 AIS girls aged 11–16 years and compared to those of 300 age-matched healthy girls. We also followed up a group of AIS girls aged 12–17 years to track the changes of BMD during peripuberty. Results showed that a significantly faster rate of anthropometric growth and higher bone-turnover in AIS might lead to increased bone length. Calcium intake in AIS was too low (b 400 mg/day) to be sufficient for optimal bone mineralization. Osteopenia in AIS may therefore result from sub-optimal bone-mineralization qual