Preparation of lyophilized human serum based reference materials with graded levels of apolipoproteins A-I and B》.pdfVIP

ClmBiochem, Vol. 21, pp. 219-223, 1988 0009-9120/88 $3.00 + .00 Printed in Canada. All rights reserved. Copyright ~ 1988 The Canadian Society of Clinical Chemists. Preparation of Lyophilized Human Serum Based Reference Materials with Graded Levels of Apolipoproteins A-I and B L. O M A R H E N D E R S O N , 1 J A C Q U E L I N E S. H A Z L E H U R S T , L I N N A R D T A Y L O R , and W. H A R R Y H A N N O N 1Division of E n v i r o n m e n t a l Health Laboratory Sciences, C e n t e r for E n v i r o n m e n t a l Health, Centers for D i s e a s e Control, Public Health Service, D e p a r t m e n t of Health and H u m a n Services, Atlanta, G e o r g i a 3 0 3 3 3 Surveys of national and international laboratories indicate that levels of high density lipoprotein (HDL) and its major among-laboratory and between-laboratory sources of variance ac- protein component, apo A-I, are associated with de- countfor the majority of variability in laboratories measuring apoli- poproteinsA-I and B. These sources of variance are amenable to creased risk of coronary heart disease and usually ac- correctionthrough the use of common quality control and reference company low levels of apo B containing lipoproteins materials. (VLDL and LDL).