Postprandial lipaemia in patients with impaired fasting glucose, impaired glucose tolerance and diabetes mellitus》.pdfVIP

d i a b e t e s r e s e a r c h a n d c l i n i c a l p r a c t i c e 8 0 ( 2 0 0 8 ) 3 8 0 – 3 8 5 available at w journal h om epage: www.els /locate/diabr es Postprandial lipaemia in patients with impaired fasting glucose, impaired glucose tolerance and diabetes mellitus S.V. Madhu a,*, S. Kant a, S. Srivastava a, R. Kant a, S.B. Sharma b, D.P. Bhadoria a a Department of Medicine, University College of Medical Sciences and GTB Hospital, Shahdara, Delhi, India b Department of Biochemistry, University College of Medical Sciences and GTB Hospital, Shahdara, Delhi, India a r t i c l e i n f o a b s t r a c t Article history: Aims: To compare the postprandial lipid responses in subjects with prediabetes (IFG and Received 27 August 2007 IGT), newly detected diabetes mellitus (NDDM) and normal glucose tolerance (NGT). Accepted 7 January 2008 Methods: Postprandial lipid responses to a standard oral fat challenge was studied in forty- Published on line 5 March 2008 four subjects who were divided after an OGTT into NGT, pure impaired fasting glucose (PIFG), pure impaired glucose tolerance (PIGT) and NDDM. Keywords: Results: There was a significantly higher postprandial triglyceride (PPTg) response with a Postprandial higher PPTg area under curve ( p = 0.004) and peak PPTg levels ( p = 0.003) in patients with Lipids NDDM but not with either PIFG ( p 0.05) or PIGT ( p 0.05) when compared with NGT. IFG Overall, PPTg responses correlated significantly wit