Potential pathological roles for oxidized low-density lipoprotein and scavenger receptors SR-AI, CD36, and LOX-1 in aortic valve stenosis》.pdfVIP

Potential pathological roles for oxidized low-density lipoprotein and scavenger receptors SR-AI, CD36, and LOX-1 in aortic valve stenosis》.pdf

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Potential pathological roles for oxidized low-density lipoprotein and scavenger receptors SR-AI, CD36, and LOX-1 in aortic valve stenosis》.pdf

Atherosclerosis 235 (2014) 398e407 Contents lists available at ScienceDirect Atherosclerosis journal homepage: www.elsevier.c om/locate/atherosclerosis Potential pathological roles for oxidized low-density lipoprotein and scavenger receptors SR-AI, CD36, and LOX-1 in aortic valve stenosis a a a a € € € Suvi Syvaranta , Mervi Alanne-Kinnunen , Katariina Oorni , Riina Oksjoki , Markku Kupari b, Petri T. Kovanen a, Satu Helske-Suihko a, * a Wihuri Research Institute, Helsinki, Finland b Division of Cardiology, Heart and Lung Center, Helsinki University Central Hospital, Helsinki, Finland a r t i c l e i n f o a b s t r a c t Article history: Objective: To clarify the potential mechanisms by which oxidized low-density lipoprotein (oxLDL) could Received 21 May 2013 contribute to the progression of aortic valve stenosis (AVS). Received in revised form Methods: We investigated a total of 46 stenotic and 20 control human aortic valves. The mRNA 29 April 2014 expression levels of scavenger receptor class A type 1 (SR-A1), CD36, Lectin-like oxidized LDL receptor-1 Accepted 19 May 2014 (LOX-1), and scavenger receptor class B type 1 (SR-B1) were stu

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