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Pre-operative growth differentiation factor 15 as a novel biomarker of acute kidney injury after cardiac bypass surgery》.pdf
International Journal of Cardiology 197 (2015) 66–71 Contents lists available at ScienceDirect International Journal of Cardiology journal homepage: www. else vi er. com/ locate/ijcard Pre-operative growth differentiation factor 15 as a novel biomarker of acute kidney injury after cardiac bypass surgery☆,☆☆ Charles Guenancia a,b,⁎,1, Abdelkader Kahli b,c,1, Gabriel Laurent a,d, Olivier Hachet a,b, Ghislain Malapert e, Sandrine Grosjean c, Claude Girard c, Catherine Vergely b, Olivier Bouchot e a University Hospital, Department of Cardiology, Dijon, France b INSERM U866, LPPCM, Dijon, France c University Hospital, Department of Anaesthesiology, Dijon, France d CNRS, UMR 5158, Le2I, Dijon, France e University Hospital, Department of Cardiothoracic Surgery, Dijon, France a r t i c l e i n f o a b s t r a c t Article history: Background: Pre-operative GDF-15 plasma levels significantly improve the prognostic value of the EuroSCORE for Received 6 December 2014 mortality after cardiac surgery. However, despite the strong correlation between GDF-15 and renal function, no Received in revised form 13 May 2015 data are available regarding the potential interest of pre-operative GDF-15 levels to improve the prediction of Accepted 12 June 2015 acute kidney injury (AKI) after cardiac artery bypass graft (CABG) surgery. Available online 17 June 2015 Methods: All patients operated on by 2 surgeons for CABG surgery at our university hospital from September
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