Paradoxical effects of KB-R7943 on arrhythmogenicity in a chronic myocardial infarction rabbit model》.pdfVIP
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Paradoxical effects of KB-R7943 on arrhythmogenicity in a chronic myocardial infarction rabbit model》.pdf
Journal of Cardiology 66 (2015) 80–87 Contents lists available at ScienceDirect Journal of Cardiology jo u rn al h om ep age: ww w.els evier.c o m/lo c ate/jjc c Original article Paradoxical effects of KB-R7943 on arrhythmogenicity in a chronic myocardial infarction rabbit model Po-Cheng Chang (MD)a,b, Hung-Ta Wo (MD)a,b, Hui-Ling Lee (MD)b,c, Ming-Shien Wen (MD)a,b, Chung-Chuan Chou (MD)a,b,* a Division of Cardiology, Department of Internal Medicine, Linko, Chang Gung Memorial Hospital, Taipei, Taiwan b Chang Gung University College of Medicine, Taoyuan, Taiwan c Department of Anesthesia, Chang Gung Memorial Hospital, Taipei, Taiwan A R T I C L E I N F O A B S T R A C T Article history: + 2+ Background: Na /Ca exchanger blockade has been reported to be anti-arrhythmic in different models. Received 9 January 2014 + 2+ The effects of KB-R7943, a Na /Ca exchanger blocker, on arrhythmogenesis in hearts with chronic Received in revised form 22 July 2014 myocardial infarction (MI) remain unclear. Accepted 5 August 2014 2+ Methods: Dual voltage and intracellular Ca (Ca ) optical mapping was performed in nine rabbit hearts
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