Normalized gradient fields for nonlinear motion correction of DCE-MRI time series》.pdfVIP

[TD.CITE]Computerized Medical Imaging and Graphics [TD.JXXX]38 (2014) 202–210[TD.JXXX.E][TD.CITE.E] Contents lists available at ScienceDirect Computerized Medical Imaging and Graphics j o u r n a l h o m e p a g e : w w w. elsev /locate/compmedimag Normalized gradient fields for nonlinear motion correction of DCE-MRI time series Erlend Hodneland a,∗ , Arvid Lundervold a,b , Jarle Rørvik b,c , Antonella Z. Munthe-Kaas d a Department of Biomedicine, University of Bergen, Bergen, Norway b Department of Radiology, Haukeland University Hospital, Bergen, Norway c Department of Clinical Medicine, University of Bergen, Bergen, Norway d Department of Mathematics, University of Bergen, Bergen, Norway a r t i c l e i n f o a b s t r a c t Article history: Dynamic MR image recordings (DCE-MRI) of moving organs using bolus injections create two different Received 28 May 2013 types of dynamics in the images: (i) spatial motion artifacts due to patient movements, breathing and Received in revised form 5 October 2013 physiological pulsations that we want to counteract and (ii) signal intensity changes during contrast Accepted 2 December 2013 agent wash-in and wash-out that we want to preserve. Proper image registration is needed to counteract the motion artifacts and for a reliable assessment of physiological parameters. In this work we present a Keywords: partial differential equation-based method for deformable multimodal image registration using normal- DCE-MRI