Micro PIXE-RBS for the study of Sr release at bioactive glass scaffoldsbiological medium interface》.pdfVIP

Nuclear Instruments and Methods in Physics Research B 306 (2013) 153–157 Contents lists available at SciVerse ScienceDirect Nuclear Instruments and Methods in Physics Research B journal homepage: www.else /locate/nimb Micro PIXE-RBS for the study of Sr release at bioactive glass scaffolds/biological medium interface Joséphine Lacroix a, Jonathan Lao a, Jean-Marie Nedelec b,c, Edouard Jallot a,⇑ a Clermont Université, Université Blaise Pascal, CNRS/IN2P3, Laboratoire de Physique Corpusculaire, BP 80026, 63171 Aubière Cedex, France b Clermont Université, ENSCCF, Institut de Chimie de Clermont-Ferrand, BP 10448, 63000 Clermont-Ferrand, France c CNRS, UMR 6296, ICCF, 63171 Aubière, France a r t i c l e i n f o a b s t r a c t Article history: Strontium is a very interesting element in bone regeneration as it can promote bone formation and limit Received 16 July 2012 bone resorption. Bone tissue engineering has a very high potential as a method for bone healing and it Received in revised form 17 September 2012 requires a 3D macroporous scaffold to serve as a support for cell growth. In that purpose, strontium contain- Available online 12 November 2012 ing bioactive glass foams made with the sol–gel foaming process are very promising scaffolds as they com- bine the high bioactivity of bioactive glasses, the beneficial effects of strontium on bone growth and a Keywords: structure that would allow cell adhesion, cell invasion and vascularization. This paper reports the synthesis PIXE-RBS