Metrological traceability in mass spectrometry-based targeted protein quantitation A proof-of-principle study for serum apolipoproteins A-I and B100》.pdfVIP

J O U R N A L O F P R O T E O M I C S 1 0 9 ( 2 0 1 4 ) 1 4 3 – 1 6 1 A v a i l a b l e o n l i n e a t w w w . s c i e n c e d i r e c t . c o m ScienceDirect w w w . e l s e v i e r . c o m / l o c a t e / j p r o t Metrological traceability in mass spectrometry-based targeted protein quantitation: A proof-of-principle study for serum apolipoproteins A-I and B100 a,⁎ a a b Nico P.M. Smit , Fred P.H.T.M. Romijn , Irene van den Broek , Jan W. Drijfhout , Martin Haexc a d a , Arnoud van der Laarse , Yuri E.M. van der Burgt , Christa M. Cobbaert aDepartment of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands bDepartment of Immunohematology and Bloodtransfusion, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands cAgilent Technologies Netherlands B.V., Amstelveen, The Netherlands dCenter for Proteomics and Metabolomics, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands A R T I C L E I N F O A B S T R A C T Article history: In this study, we have followed up on previous liquid chromatography (LC) multiple reaction Received 12 March 2014 monitoring (MRM) mass spectrometry (MS) approaches for measurement of apolipoprotein Accepted 16 June 2014