Modulation of IFN-γ Receptor 1 Expression by AP-2α Influences IFN-γ Sensitivity of Cancer Cells》.pdfVIP

Modulation of IFN-γ Receptor 1 Expression by AP-2α Influences IFN-γ Sensitivity of Cancer Cells》.pdf

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Modulation of IFN-γ Receptor 1 Expression by AP-2α Influences IFN-γ Sensitivity of Cancer Cells》.pdf

The American Journal of Pathology, Vol. 180, No. 2, February 2012 Copyright © 2012 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved. DOI: 10.1016/j.ajpath.2011.10.040 Growth Factors, Cytokines, and Cell Cycle Molecules Modulation of IFN- Receptor 1 Expression by AP-2 Influences IFN- Sensitivity of Cancer Cells Changguo Chen,*† Liang Guo,* Ming Shi,* Interferon (IFN)- is a key proinflammatory cytokine and Ming Hu,† Meiru Hu,* Ming Yu,* Tianyou Wang,‡ plays crucial roles in regulating both innate and adaptive Lun Song,* Beifen Shen,* Lu Qian,* and immunity.1,2 The findings that IFN- protects the host Ning Guo* against the growth of chemically induced, spontaneously arising, and transplantable tumors have generated great From the Department of Molecular Immunology,* Institute of interests in the obligate activities of IFN- in cancer im- Basic Medical Sciences, Beijing; the Department of Clinical munoediting, which refers to the dual anti-tumor/tumor- Laboratory,† the Navy General Hospital, Beijing; and the Capital 3–6 ‡ sculpting actions of IFN- and the immune system. Institute of Pediatrics, Beijing, China

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