盐酸法舒地尔治疗肺源性心脏病心力衰竭初探.docVIP

盐酸法舒地尔治疗肺源性心脏病心力衰竭初探 　　作者：周长红，孙云春　 作者单位：401324 重庆，重庆市九龙坡区第四人民医院 【摘要】 目的 观察盐酸法舒地尔治疗肺源性心脏病(cor pulmonale，CP)心力衰竭(heart failure，HF)的疗效。方法 将60例肺源性心脏病心力衰竭患者随机分为治疗组和对照组，每组各30例，分别采用静脉滴注盐酸法舒地尔30mg q12h 和静脉滴注酚妥拉明10mg qd，治疗2周。治疗前后观察两组临床疗效，做血气分析检查。结果 治疗组的总有效率(83.33%)高于对照组(73.33%)，但差异无显著性(P0.05);治疗组的显效率(70.00%)高于对照组(40.00%)，差异有显著性(P005)。治疗组的动脉血氧分压、氧饱和度及二氧化碳分压指标改善均高于对照组，差异均具有显著性(P0.05)。结论 盐酸法舒地尔可以试用于治疗肺源性心脏病心力衰竭。 　　【关键词】 盐酸法舒地尔,酚妥拉明,心力衰竭 　　[Abstract] Objective To observe the therapeutic effects of Fasudil Hydrochloride on treating heart failure(HF) of cor pulmonale(CP). Methods Sixty patients with HF of CP were divided into two groups randomly and equally.The treatment group was treated with Fasudil Hydrochloride 100 mg,q12h，ivgtt, for 14 days.Control group was treated with Phentolamine 10mg qd，ivgtt, for 14 days.Therapeutic effects and blood gas analysis were got before and after treatment in both groups.Results The total effective rate(83.33%)of the treatment group was no significantly higher than that(73.33%) of the control group (P0.05),but the excellence rate (70.00%)of the unite treatment grout was significantly higher than that(40.00%) of the control group(P0.05).The arterial partial pressure of oxygen, oxygen saturation and partial pressure of carbondioxide were significantly improved after treatment in both two groups(all P0.05).Conclusion It is possible to treat HF of CP with Fasudil Hydrochloride. 　　[Key words] Fasudil Hydrochloride; Phentolamine; heart failure; cor pulmonale; therapeutic effect 　　肺源性心脏病(cor pulmonale，CP)是一种常见病、多发病，由于肺动脉高压引起右心室负荷过重所致。酚妥拉明是临床治疗肺源性心脏病心力衰竭(heart failure，HF)最主要的药物，但临床疗效和应用有限，有必要寻找新的药物用于临床。最近研究[1,2]表明法舒地尔能够降低缺氧性肺动脉高压(hypoxic pulmonary hypertension，HPH)鼠的肺动脉压力及肺血管阻力。但少有将盐酸法舒地尔用于治疗肺源性心脏病心力衰竭的报道。本论文进行盐酸法舒地尔治疗肺源性心脏病心力衰竭初步探讨。 　　1 资料与方法 　　1.1 一般资料 　　纳入60例肺源性心脏病心力衰竭患者，心功能不全Ⅲ级，均符合1997年全国CP诊断标准。 其中男30例，女30例，年龄48～81(664±4.5)岁，原发病均为慢性支气管炎，心衰病程3～15(6.2±3.5)年。将60例肺源性心脏病心力衰竭患者随机分为治疗组和对照组。两组的年龄、性别差异无显著性(P0.05)。排除标准：(