Factors Associated with Generic and Disease-specific Quality of Life in Epilepsy.pdfVIP

Factors Associated with Generic and Disease-specific Quality of Life in Epilepsy.pdf

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Factors Associated with Generic and Disease-specific Quality of Life in Epilepsy.pdf

228 BiomedEnvironSci,2011;24(3):228—233 OriginalArticle FactorsAssociatedwithGenericandDisease—specificQualityofLifeinEpilepsy HUANG HuaPin ,CHEChunHui,LIU ChangYun ,JIANG Fang,andMAO XiaoHong /.DepartmentofNeurology,UnionHospitalAffiliatedtoFujianMedicalUniversity,Fuzhou350001,Fujian,China 2.DepartmentofTraditionalChineseMedicine,UnionHospitalAffiliatedtoFujianMedicalUniversity,Fuzhou 350001,Fujian,China Abstract Objective Toinvestigatetheassociationbetweenqualityoflife(O!OL)andsociodemographicfactors, clinicalseizurefactors.depressionandanxietyinpatientssufferingfrom epilepsy. Methods Weexamined141consecutivepatientswithepilepsy(meanage25.8+9.6,61.7%male).All patientscompletedtheSelf-RatingDepressionScale,Self-RatingAnxietyScale,WHOO,OL—BREFand O.OLIE一31(Chineseversion).Multiplelinearregressionanalyseswereappliedtoinvestigatefactors impactonO!OL. Results TheresultsreveaIedthatscoresontwodomainsoftheWHOQOL—BREF(i.e.,physicaIand psychologicaIdomains,P0.05)weresignificantlylowerintheepilepsygroupcomparedwiththecontroI group.Mu…tpie regression analyses showed that anxiety.depression and course explained approximately40%ofthevarianceinpatientsQOL.Anxietywasconsistentlythestrongestpredictorof Iowerscoreson almostaIIO!OLdomains.In addition.the severity ofdepressive symptomswas significantlyassociatedwithIowerscoresacrossmanyO,OLdomains. Conclusion OurfindingssuggestthatO,OLIEscoresm ightbesubstantiallyaffected bythepresence andseverity ofanxietysymptomsand,to a lesserdegree,ofdepressive symptomsand prolonged courseofillness.Incontrast,clinicalseizurevariableshadaweakerassociationwithO.OL.Healthcare professionalsshouldbeawareofthesignificanceofpatientsemotionalstateandoftheroleitplaysin

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